Massachusetts Institute of Technology

National University of Singapore

Aim Biotech Pte. Ltd.

Sei Hien Lim

Roger Dale Kamm

Chee Mun Kuan

Michael Raghunath

Swee Khuan Lim

Andrea Pavesi

A microfluidic platform for investigating cell-based interactions with a chip base is made of a suitable plastics material with the appropriate optical properties. The chip base has a plurality of ports in fluid communication with a microfluidic channel for containing a culture medium in which cells are held. A gas permeable laminate is bonded to a bottom surface of the chip base. Each port has an internal inlet, connecting the port with the microfluidic channel, and a trough for containing a small reservoir of culture medium fluid adjacent to the inlet. When in use, culture medium can be aspirated from the microfluidic channel via the trough rather than directly via the internal inlet.

Microfluidic platform for investigating cell-based interactions

The invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1&#x3b1; (HIF-1&#x3b1;). In another aspect, the invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1&#x3b1; (HIF-1&#x3b1;) and one or more lysophospholipids. In addition, the invention is directed to methods of generating prevascularized tissue, methods of generating a vascular network in a device and compositions thereof.

Compositions and methods for neovascularization

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Singapore, Singapore

Sei Hien Lim