Abbott Laboratories Corporation

Sean Garvey

Suzette Pereira

Neile Edens

Eric Torgerson

Roger Tyre

Paul W Johns

Stephen Joseph Demichele

Christopher T Cordle

Steven Hertzler

Powdered nutritional products containing branched-chain amino acids and a sugar alcohol are provided. The branched-chain amino acids in the powdered nutritional product exhibit improved solubility and thus improved dissolution upon reconstitution of the powdered nutritional product.

Powdered nutritional product containing branched-chain amino acids and a sugar alcohol

A nutritional composition comprises fat, protein and carbohydrate such that the fat provides from about 60 to about 90% of the total calories of the composition, the protein provides from about 10 to about 30% of the total calories of the composition, and the carbohydrate provides from about 0.1 to about 15% of the total calories of the composition, and the composition comprises from about 0.01 to about 10 wt % beta-hydroxy-beta-methylbutyrate (HMB). A method of achieving or sustaining metabolic ketosis in an individual comprises administering the nutritional composition to the individual. A method of maintaining lean body mass and muscle strength in an individual during dietary ketosis comprises administering the nutritional composition to the individual.

Ketogenic nutritional compositions

Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition.

Methods of maintaining and improving muscle function

Disclosed herein are methods for enhancing the efficacy of epigallocatechin gallate ('EGCg') in mitigating skeletal muscle loss in a subject. Providing EGCg to a subject in a nutritional composition reduces muscle protein degradation, thereby mitigating skeletal muscle loss in the subject. The combination of EGCg with zinc in a nutritional composition enhances the mitigating effect that EGCg has on muscle loss. Specifically, when used in combination, a nutritional composition containing both EGCg and zinc requires less EGCg to obtain the same mitigating effect that occurs in the same nutritional composition containing EGCg but no zinc.

Growing community of inventors

Columbus, OH, United States of America

Sean Garvey