Genomatica, Inc.

Scott Allen Frykman

Zhihao Hu

Louis G Hom

Vikranth Arlagadda

Eli S Groban

Fernando A Sanchez-Riera

Derek L Greenfield

Bernardo Moura Torres Da Costa

Isolde Callihan

Sankaranarayanan Venkiteswaran

Stephen Thomas Payne

Leland Ken Wong

Fernando A Sanchez-riera

The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives.

XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.

Methods and compositions for improved production of fatty acids and derivatives thereof

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South San Francisco, CA, United States of America

Scott Allen Frykman