Trana Discovery, Inc.

Merial Limited

Rhone-poulenc Agro

Maverick Biofeuls, Inc

Samuel Perry Yenne

Richard H Guenther

Andrzej Malkiewicz

Winnell H Newman

Dan Mitchell

James William Smith

Jerzy Ryszard Szewczyk

Philippe Jeannin

David Bradin

Steven E Peterson

Jeffrey Harrison

Joseph Christopher Ellis

Eric Cumming

Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.

Identification of selected spectrum antibiotics

Methods of inhibitingpropagation, and screening for compounds that inhibitpropagation, are described. A method of inhibitingpropagation comprises either inhibiting or stabilizing ribosomal binding of a specifictRNA in theby an amount sufficient to inhibitprotein expression. A method of screening for compounds useful for inhibitingpropagation comprises contacting a specifictRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.

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A combined anaerobic digester system and gas-to-liquid system is disclosed. The anaerobic digester requires heat, and produces methane. The gas-to-liquid system produces heat, and converts methane to higher-value products, including methanol and formaldehyde. As such, the combination of the two systems results in significant savings in terms of capital and operating expenses. A process for producing bio-formaldehyde and bio-formalin from biogas is also disclosed.

Combined anaerobic digester and GTL system and method of use thereof

Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.

Compositions and methods for the identification of inhibitors of protein synthesis

Process and composition for the antiparasitic treatment of the surroundings of animals

Processes for the antiparasitic control of darkling beetles utilizing 1-arylpyrazole insecticides and for applying said insecticides to animal litter, especially for animal rearing, are described. Also described are mixtures of carbaryl and 1-arylpyrazole insecticides.

Growing community of inventors

Raleigh, NC, United States of America

Samuel Perry Yenne