University of California

Aduro Biotech Inc.

Russell E Vance

Thomas W Dubensky, Jr

Laura Hix Glickman

David Braun Kanne

David B Kanne

Meredith Lai Ling Leong

Edward Emile Lemmens

Ming Chen Hammond

Stephen C Wilson

Elie J Diner

Dara Burdette

Methods and compositions are provided for increasing the production of a type I interferon (IFN) in a cell. Aspects of the methods include increasing the level of a 2′-5′ phosphodiester linkage comprising cyclic-di-nucleotide in a cell in a manner sufficient to increase production of the type I interferon (IFN) by the cell. Also provided are compositions and kits for practicing the embodiments of the methods.

Cyclic di-nucleotide induction of type I interferon

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2',5&#x2032;,2&#x2032;,5&#x2032; and 2&#x2032;,5&#x2032;,3&#x2032;,5&#x2032; CDNs, and preferably Rp,Rp stereoisomers thereof.

Compositions and methods for activating 'stimulator of interferon gene'-dependent signalling

Compositions and methods for activating stimulator of interferon gene-dependent signalling

Growing community of inventors

Albany, CA, United States of America

Russell E Vance