Basf Aktiengesellschaft

Pharmazell Gmbh

Basf Se Corporation

Eppendorf Ag

Rolf Schmid

Bernhard Hauer

Ulrich Schwaneberg

Juergen Pleiss

Markus Fischer

Qing-shan Li

Jutta Schmitt

Wolfgang Wohlleben

Arno Aigner

Sabine Lutz-Wahl

Till Bachmann

Peter Fischer

Tilo Habicher

Dirk Weuster-Botz

Cecilia Kvarnström Branneby

Michael Braun

Steffen Maurer

Luo Sha Liu

Frank Zocher

Oliver Scherr

Claudia Schmidt-Dannert

Daniel Appel

Satoshi Ezaki

Stefanie Häfele

Rainer Merkl

Francesca Blasco

Steffen Christian Maurer

Peter Trodler

Vlada Beniaminovna Urlacher

Holger Schulze

Danni Liu

Norbert Huber

Lou Liu

Monika Müller

Markus Enzelberger

Dietmar Häring

Luo Liu

Cecilia Kvarnstroem Branneby

Cecilia Branneby

Monika Rusnak

The invention relates to novel 7&#x3b2;-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus, especially of the strain, to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.

7&#x3b2;-hydroxysteroid dehydrogenases and their use

The invention relates to 12 &#x3b1;-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 &#x3b1;-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 &#x3b1;-hydroxysteroids using said enzyme, a method for enzymatic reduction of 12-ketosteroids using said enzyme, a method for qualitative or quantitative determination of 12-ketosteroids and/or 12&#x3b1;-hydroxysteroids using said 12&#x3b1;-hydroxysteroid dehydrogenases and a method for production of ursodesoxycholic acid, comprising the enzyme-catalyzed cholic acid oxidation using said 12 &#x3b1;-hydroxysteroid dehydrogenases.

7 &#x3b1;-hydroxysteroid dehydrogenase knockout mutants and use therefor

A protein having acrylation activity having a polypeptide sequence derived from SEQ ID NO: 1 or NO:2 by introducing at least one of the following amino acid substitutions: L278A, L278V, W104F, T42A, S47A.

CALB muteins and their use

The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.

Modified cytochrome P450 monooxygenases

The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The invention also relates to methods for microbiologically oxidizing different organic substrates, such as methods for producing indigo and indirubin.

Cytochrome p450 monooxygenases and their use for oxidizing organic compounds

The present invention relates to an improved method for determining nucleotide sequences or nucleotide sequences on biochips/micro-assays, for example, using p53 mediated hybridization. The present invention relates particularly to the use of p53 polypeptides in determining changes in nucleotide sequences.

Method for determining nucleotide sequences

The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genussp., to nucleotide sequences encoding them, to the recombinant production of these monooxygenases and to their use for the microbiological oxidation of organic compounds.

Cytochrome P450 monooxygenases consisting of thermophilic bacteria

Modified cytochrome p450 monooxygenases

A process for preparing a hydroxylation catalyst by

Method for producing a hydroxylation catalyst and the use thereof

A description is given of epoxide hydrolases from bacteria of the genus , a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting epoxide hydrolase activity and the use of bacteria of the genus and of the resultant epoxide hydrolases for enantioselective epoxide hydrolysis.

Epoxide hydrolases from streptomyces

The invention relates to a process for the oxidation of substituted trimethylcyclohexenyl compounds in the presence of microorganisms of the order Actinomycetales and to the use of microorganisms in oxidation reactions.

Method for the oxidation of substituted trimethylcyclohexenyl compounds with bacteria of the family Streptomycetaceae

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Stuttgart, Germany

Rolf Schmid