United States of America, as Represented by the Secretary of Agriculture

The University of Texas System

Robin C Anderson

David J Nisbet

Larry H Stanker

William E Pinchak

Yong Soo Jung

Elizabeth A Latham

Robert E Droleskey

The present invention concerns novel probiotic compositions that increase nitrate- and nitrite-reduction in animals such as ruminants. The present invention thus provides compositions and methods for reducing nitrate/nitrite toxicity in such animals, or prophylactically protecting such animals from the effects of toxicity, such as methemoglobinemia. A novel strain of an unspeciated bacterial strain related tospecies with nitrate- and nitrite-reducing capabilities is described. In conjunction with nitrate-supplemented diets, the probiotics of the present invention can also be utilized to reduce methanogenesis in livestock. Furthermore, the probiotic compositions of the present invention can be used to reduce the number and kind of food-borne pathogens, such asand

Nitrate- and nitrite-reducing probiotic feed additive

The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in animals. Populations of enteropathogenic bacteria may be substantially reduced or eliminated by treatment of animals with an effective amount of 2-nitropropanol, 2-nitroethane or 2-nitroethanol. The compounds may be administered orally, providing a reduction in the populations of the enteropathogenic bacteria in the alimentary tract of the animal, or they may be applied externally onto the animal to reduce the populations of any such bacteria which may be present as contaminants on the surface of the animal. The method and compositions are particularly useful for the control ofspecies, enteropathogenicspecies, and

Use of 2-nitropropanol, 2-nitroethane, and 2-nitroethanol for control of microbial pathogens

The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in animals. Populations of enteropathogenic bacteria may be substantially reduced or eliminated by treatment of animals with an effective amount of the compound X (ClO ) , wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0. The compounds may be administered orally, providing a reduction in the populations of the enteropathogenic bacteria in the alimentary tract of the animal, or they may be applied externally onto the animal to reduce the populations of any such bacteria which may be present as contaminants on the surface of the animal. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic , and Clostridia species.

Use of chlorate ion or preparations thereof for reduction of food borne pathogens

The invention provides a method for treating infections in animals which are caused by toxin-producing enteric bacterial pathogens, including Shigella species, enterohemorrhagic , and enterotoxigenic . Receptors expressed by animal cells which typically recognize these bacterial toxins may be modified by administration of swainsonine compounds to the animal, thereby effectively inhibiting toxin binding to the cells.

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College Station, TX, United States of America

Robin C Anderson