Ambrx, Inc.

Other

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Calder Biosciences Inc.

Roberto Mariani

Nick Knudsen

Vadim Kraynov

Jason Pinkstaff

Anna-Maria A Hays Putnam

Thomas P Cujec

William M Keefe

Lillian Skidmore

Ho Sung Cho

Jason Scott McLellan

David C Litzinger

Anna-Maria A Hays

Thomas O Daniel

Bruce E Kimmel

Lucio Iacobucci

Christopher P Marshall

Lillian Ho

Claudio Bertuccioli

Peter Joseph Alff

Maurizio Ruspantini

Massimiliano Marcoccia

Troy Edward Wilson

Zhenwei Miao

Junjie Liu

Christopher Marshall

Stuart Bussell

Bee-Cheng Sim

Alan Koder

Mark Yondola

Aaron Zomback

Sonal Gidwani

Wiliam M Keefe

Lillian Skidmore (Nee Ho)

Theresa Morrow

Christopher Patrick Marshall

Jason Scott Mclellan

In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Conformationally stabilized RSV pre-fusion F proteins

Modified FGF-21 polypeptides and uses thereof are provided.

Modified FGF-21 polypeptides with non-naturally encoded amino acids

The present invention provides mutant RSV F molecules, such as those that can be, or are stabilized, in a pre-fusion conformation by the introduction of one or more DT cross-links. The present invention also provides methods of making such mutant RSV F molecules, compositions comprising such mutant RSV F molecules, and methods of use of such mutant RSV F molecules, for example in vaccination methods, therapeutic methods, and antibody production methods.

A beverage dispensing machine designed for aircraft use has compact dimensions, is low-weight and satisfies the safety requirements and standards applicable in that sector. The beverage dispensing machine can dispense both large quantities of a beverage, such as 1.6 liters of American coffee or tea, inside a jug positioned inside an appropriate seat, and smaller quantities of hot water (typically 150 ml), which can be used to prepare beverages, via a nozzle situated on the outside thereof. In one embodiment, the beverage dispensing machine includes a bottom jug retention system having a locking lever hinged on spiral seats to keep the jug stationary during the dispensing of the beverage.

Beverage dispensing machine

Modified FGF-21 polypeptides and their uses

The present invention relates to a water heating system (part number lacubucci HF Aerospace AS0012480) for beverage dispensing machines. The heater has a double system: a pre-chamber, preferably of the spirally wound type, for pre-heating the water along a predefined path, and a chamber which is always full of water heated with resistors making direct contact with the water (or in some cases with a protection jacket) for maximizing the efficiency.

Heating device

Modified FGF-21 polypeptides comprising non-naturally encoding amino acids and their uses

Nucleic acids encoding modified FGF-21 polypeptides comprising non-naturally occurring amino acids

Methods of treatment using modified FGF-21 polypeptides comprising non-naturally occurring amino acids

Modified FGF-21 polypeptides comprising non-naturally occurring amino acids

Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives

Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.

Pegylated human interferon polypeptides

Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.

Biosynthetic polypeptides utilizing non-naturally encoded amino acids

Growing community of inventors

San Diego, CA, United States of America

Roberto Mariani