Georgetown University

Robert R Clarke

Milton L Brown

Sivanesan Dakshanamurthy

Charles F Hammer

Jacqueline Smith

Alem Ghiorghis

Ayesha N Shajahan-Haq

Erica A Golemis

Philip S Schein

Louis M Weiner

Ilya G Serebriiskii

Abdolhossen Talebian

Dianna C Green

Fabio Leonessa

Abdel H Talebian

Rochelle E Nasto

Small molecule inhibitors of XBP1 splicing by IRE1&#x3b1; are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Small molecule inhibitors of XBP1 splicing

The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the group consisting of BLOC1S1, CDC2L1, CNOT1, DDX54, EIF3I, FANCG, FBP1, IER2, KIF1A, LCK, NR2F1, PNRC1, POLR2A, POLR2B, POLR2C, PRPF6, PSMB4, PSMC5, PSMD1, RPS2, SCNN1A, SF3A3, TAF2, TOB1 and TSC22D4.

Methods of inhibiting proliferation of estrogen-independent cancer cells

Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Small molecules for treating breast cancer

The present invention is directed to compounds of formula I ##STR1## wherein the substituents are as defined in the specification. Also disclosed are compositions and method of use of the compounds.

Progesterone analogs to reverse multidrug resistance

The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to supress the growth of cancer cells. The invention also relates to processes for the preparation of the mitomycin derivatives of the invention.

Mitomycin derivatives having reduced bone marrow toxicity, processes for

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Bethesda, MD, United States of America

Robert R Clarke