Evonik Degussa Gmbh

Evonik Technochemie Gmbh

Evonik Operations Gmbh

Robert Gerstmeir

Wilfried Claes

Andreas Karau

Kay Marin

Nicolas Morin

Hugo Ramos-Vera

Iris Wiegrabe

Iris WIEGRÄBE

The invention relates to a process for the production of amino acids and keto acids using microorganisms, in which a promoter inducible by propionate makes possible the regulated expression of certain genes.

Method for producing L-leucine, L-valine, L-isoleucine, &#x3b1;-ketoisovalerate, &#x3b1;-keto-beta-methylvalerate, or &#x3b1;-ketoisocaproate using recombinant Corynebacteria that contain the ilvBN operon which can be induced by propionate

The present invention refers to a method for the preparation of 2-keto carboxylic acid having the general formula R&#x2014;CO&#x2014;COOH, wherein Ris a branched alkyl group having 3 to 7 carbon atoms, or a salt thereof, comprising a fermentation step wherein a microorganism is grown in a culture medium in order to provide a culture broth containing 2-keto carboxylic acid or a salt thereof.

Method for the preparation of 2-keto carboxylic acid

The invention relates to an isolated nucleotide sequence encoding an amino acid sequence that is at least &#x2267;90%, &#x2267;92%, &#x2267;94%, &#x2267;96%, &#x2267;97%, &#x2267;98%, &#x2267;99% or 100%, preferably &#x2267;97%, particularly preferably &#x2267;98%, very particularly preferably &#x2267;99%, and extremely preferably 0%, identical to the amino acid sequence of SEQ ID NO:2, wherein SEQ ID NO:2, at position 553, or at a corresponding position of the amino acid sequence, has a proteinogenic amino acid other than L-tyrosine, to a microorganism comprising the nucleotide sequence and also to a process for producing fine chemicals using this microorganism.

Feedback-resistant alpha-isopropylmalate synthases

A process for the fermentative preparation of L-ornithine using microorganisms characterized by an increased export of the amino acid.

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Werther, Germany

Robert Gerstmeir