Mars, Incorporated

Senomyx, Inc.

Ortho-Mcneil Pharmaceutical Corp.

Xenon Pharmaceuticals Inc.

Incyte San Diego Inc.

Richard Masten Fine

Catherine Tachdjian

Andrew John Taylor

Xiaodong Li

Albert Zlotnik

Guy Servant

Qing Chen

Xiao-Qing Tang

Xinshan Kang

Mark Zoller

Donald Karanewsky

Shaoyi Sun

Boris Klebansky

Scott Joseph McGrane

Matthew Ronald Gibbs

Feng Zhang

Marketa Rinnova

Haitian Liu

Sara Werner

Vincent Darmohusodo

Hong Zhang

Sara L Adamski-Werner

Lyle W Spruce

Vishnumurthy Kodumuru

Joseph R Fotsing

Jeffrey Robert Hammaker

Goran Petrovic

Rachel D A Kimmich

Jerry Wallace Skiles

Jeffrey Yamamoto

Scott Joseph Mcgrane

Magnus Pfahl

Michael D Winther

Heinz W Gschwend

Hussien A Al-Shamma

Daniel F Harvey

Mark Gray-Keller

Wenbao Li

James Zapf

Jianhua Guo

Karine Jakubowicz-Jaillardon

Andrea Fanjul Giachino

Alan D Steigerwald

Jian-min Fu

Donald S Karanewsky

Rachel Da Kimmich

Sara Adamski-Werner

Rachel DA Kimmich

A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

Compounds that modulate fatty acid receptor activity and pet food products containing the same

The presently disclosed subject matter relates to methods of screening raw materials and pet food products to manufacture a palatable pet food product. The presently disclosed subject matter also relates to methods for identifying compounds that modulate the activity and/or expression of a taste receptor.

Screening methods using GPRC6A taste receptors and pet food products and compositions prepared using the same

The present disclosure provides methods for identifying compounds that modulate the activity and/or expression of GPR92, wherein said compounds can be incorporated into flavor compositions that can be used to modify the taste and/or palatability of pet food products. In certain non-limiting embodiments, the present disclosure provides a method for identifying a composition that modulates the activity of a GPR92 receptor comprising (a) contacting a test agent with a GPR92 receptor, (b) determining the activity of the GPR92 receptor, and (c) selecting as the composition, a test agent that increases the activity of the GPR92 receptor.

Methods for identifying modulators of GPR92

Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

Methods for modulating taste receptors

Methods for identifying compounds that modulate the activity and/or expression of a calcium-sensing receptor, wherein said compounds can be incorporated into flavor compositions that can be used to modify the kokumi taste and/or palatability of pet food products.

Methods for identifying modulators of calcium-sensing receptors

The present invention relates to a method of identifying a compound that binds to or modulates the activity of one or more polypeptides encoding one or more receptors that are involved in the detection and perception of fatty acids.

Methods for increasing palatability of pet foodstuff

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Modulation of chemosensory receptors and ligands associated therewith

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.

Methods of enhancing sweet taste of compositions using substituted thieno{2,3-D}pyrimidines

The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors: These compounds are useful as sweet taste enhancers in comestible or medicinal compositions. The present invention also provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

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Ridgewood, NJ, United States of America

Richard Masten Fine