Other

University of California

Richard L Wagner

Brian L West

John D Baxter

Peter J Kushner

Robert J Fletterick

Thomas S Scanlan

Andrew K Shiau

James J Apriletti

William Weber

Keith R Yamamoto

Weijun Feng

Ted Gurnard

Beatrice Darimont

The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to this sites. The methods can be applied to other nuclear receptors including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, and AR.

Methods for modulating nuclear receptor coactivator binding

A security closure for enclosing the top opening of a container includes a cap having a plurality of flexible, independently movable skirt portion segments which are positionable under a rib of the container. A wire engaging the skirt portion segments cooperates with a pivoted lever to move the skirt portion segments into latching position relative to the container and a lock is employed to maintain the wire tightened against the skirt portion segments.

Security closure for a container

The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as &ldquo;TR&rdquo;). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

Nuclear receptor ligands and ligand binding domains

A clamping assembly with at least two clamping members with inner surfaces facing towards each other and outer surfaces facing away from each other, a bolt passes through holes formed in the clamping members, the bolt including a bolt head and a threaded section, the inner surfaces including means for gripping work surface, such that when the bolt is tightened, work pieces are clamped together.

Clamping assembly

Growing community of inventors

San Francisco, CA, United States of America

Richard L Wagner