The Johns Hopkins University

Reid E Messersmith

Christopher M Hoffman, Jr

Mairead E Bartlett

Konstantinos Gerasopoulos

Spencer A Langevin

James K Johnson

Adam W Freeman

Felix C Sage

Scott A Shuler

Brian M Koronkiewicz

A microcapsule for use with an underwater adhesive includes a shell including nanoclay platelets and a polyurea product of an interfacial polymerization of a polyamine and an aromatic polyisocyanate. The microcapsule further includes a core composition encapsulated by the shell. The core composition includes a base catalyst for formation of a polyurethane, a polyol, and a hydrophilic solvent.

Microcapsules for use with polyurethane and epoxy adhesives

A bifunctional linker of Formula 1 wherein in Formula I, at least one of Rto Ris —COORand Ris —C-Calkyl(C-Calkynyl) or —C-Calkyl-C-Calkenyl(C-Calkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.

Bifunctional linker for bisconjugation, method of synthesis, and method of use

An anti-fouling coating comprising a polymeric compound, wherein a backbone of the polymeric compound is covalently bonded to a quorum sensing inhibitor, and wherein the anti-fouling coating has substantially no bactericidal activity, the quorum sensing inhibitor is substantially non-leaching from the anti-fouling coating, or both.

Anti-microbial coating for the prevention of biofouling

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Jessup, MD, United States of America

Reid E Messersmith