Merck + Co., Inc.

Qinjian Zhao

Robert D Sitrin

Walter E Manger

Shilu Wu

David P Gervais

Shishir Gadam

Dicky G Abraham

Juan Gimenez

The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts of active ingredient, vaccines with higher immunogenicity and combination vaccines which produce and protective immunization against infection by hepatitis B virus and other infectious agents.

Recombinant hepatitis B surface antigen

Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The resultant matured VLPs are more stable, and can be used to make a vaccine formulation with increased shelf life and higher potency.

Process for making human papillomavirus virus-like particles with improved properties

Growing community of inventors

Ambler, PA, United States of America

Qinjian Zhao