University of California

University of Illinois

Pui-Yan Kwok

Paul R Selvin

Ming Xiao

Ting-Fung Chan

Matthew Gordon

Mathew Gordon

A polynucleotide is barcoded using a method whereby an isolated, individual polynucleotide is immobilized on a solid phase and stretched, targets are labeled using target-specific hybridization probes, and an individual label of an unamplified probe at each of the labeled targets is optically detected. The order of the labels is determined to form a barcode representation of the polynucleotide wherein the targets and their relative positions are represented.

Polynucleotide barcoding

Improved methods of genetic haplotyping and DNA sequencing and mapping, including methods for making amplified ssDNA, methods for allele determination, and a DNA barcoding strategy based on direct imaging of individual DNA molecules and localization of multiple sequence motifs or polymorphic sites on a single DNA molecule.

Methods for determining genetic haplotypes and DNA mapping

Growing community of inventors

San Francisco, CA, United States of America

Pui-Yan Kwok