Defence Research Development Organisation

The Director General, Defence Research and Development Organisation

Pradeep Kumar Gupta

Krishnamurthy Sekhar

Kumaran Ganesan

Ramesh Chandra Malhotra

Laxmi Manral

Ambati Narasimha Rao

Asheesh Kumar Jain

Shri Prakash

The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride monohydrate with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-AP), (b) reacting the 4-AP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80&#xb0; C.

Method for the preparation of fentanyl

A process for the preparation of n-heneicosane is disclosed. The process comprises (a) reacting 2,4-alkaneanedione with 1-bromooctadecane in absolute ethanol in the presence of 18-crown-6 as catalyst to produce 2-heneicosanone; and (b) reducing said 2-heneicosanone using hydrazine hydrate and potassium hydroxide in ethylene glycol to obtain n-heneicosane.

Process for the preparation of n-heneicosane

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Gwalior, India

Pradeep Kumar Gupta