Icos Corporation

Deltagen Research Labs, LLC

Phyllis S Goldman

David L McElligott

Erik Christenson

Anthony J DeMaggio

Kerry W Fowler

Jaimie Karyn Rueter

Danwen Huang

Qin Jiang

Pavel E Zhichkin

Graham Beaton

Wilna J Moree

Russell Dahl

David John Fairfax

Helge A Reisch

Ren Hua Song

Anthony J Demaggio

Dan Herendeen

Jaimie E Bertino

Lisa H Bourdon

The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the hPARP2 polypeptides, antibodies that are immunoreactive with the hPARP2 polypeptides. In addition, there are provided methods for identifying specific binding partners of hPARP2, and more particularly methods for identifying binding partners that modulate biological activity of hPARP2. Methods of modulating biological activity of hPARP2 in vitro and in vivo are also provided.

Human poly(ADP-ribose) polymerase 2 materials and methods

The present invention provides compounds comprising a bicyclic aryl moiety, such as 2H-phthalazin-1-one or derivatives thereof, compositions comprising the same, and methods for producing and using the same. In particular, the present invention provides compounds of the formula:or a pharmaceutically acceptable salt, a hydrate, a solvate, or a prodrug thereof; where Q, Qand Y are those defined herein.

PARP inhibitors

Human poly (ADP-ribose) polymerase 2 materials and methods

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Bothell, WA, United States of America

Phyllis S Goldman