Scotia Holdings Plc.

Other

Philip Knowles

David F Horrobin

Mehar S Manku

Austin McMordie

Peter Redden

Andrea Pitt

Paul Andrew Wakefield

John C Stewart

Paul Bradley

A nutritional, cosmetic or pharmaceutical formulation comprising esters of polyethylene glycol in which the polyethylene glycol chain is terminated at one end by a polyunsaturated fatty acyl group, preferably C -C and at the other end by a C -C alkyl group, preferably a methyl group.

Polyethylene glycol esters of polyunsaturated fatty acids

1,3-propane diol esters and ethers and methods for their use in drug delivery

Compounds of structure (I), and when for use in therapy: where R,is an acyl group derived from a C,fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R,is as R,the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R,is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C,-C,alkyl group.

Fatty acid esters as bioactive compounds

Optimum conditions for prostaglandin synthesis are provided by internally administering an ascorbic-6-acid ester of gamma-linolenic acid or an ascorbic-6-acid ester of dihomo-gamma-linolenic acid.

Methods of treatment using ascorbyl gamma linolenic acid or ascorbyl dihomo-gamma-linolenic acid

Nicotinic acid esters and pharmaceutical compositions containing them

N-alkylpolyhydroxyamine salts of polyunsaturated fatty acids

Triglycerides with at least two different acids chosen from 6-desaturated essential fatty acids and oleic acid, useful in nutrition and in medicine.

Triglycerides

Ascorbyl-GLA or Ascorbyl-DGLA in medicaments for treatment of asthma and other disorders.

Fatty acid derivatives

A triglyceride for use in therapy or as a nutritional supplement, or a composition containing a triglyceride, wherein the triglyceride comprises a fatty acid selected from gamma-linolenic acid and the n-6 EPAs naturally derived therefrom and stearidonic acid and the n-3 EFAs naturally derived therefrom, forming a triple ester with glycerol or alternatively forming a double ester in which the other esterifying acide is a single residue of linoleic acid, with the proviso that the di-gammalinolenoyl-mono-linoleoyl glyceride if selected is used as a preparation containing more than 20% by weight thereof.

Triglycerides of fatty acids

An NSAID in the form of a compound with an essential fatty acid or essential fatty acid alcohol, particularly an NSAID as listed in categories 1 to 9 herein. Further, a method of preparation of a medicament for the treatment including prophylatic treatment of rheumatoid arthritis, osteoarthritis and related disorders; dysmenorrhoea; dementias, including Alzheimer's disease; or any other inflammatory or other conditions specified herein, wherein the said NSAID is used.

Growing community of inventors

Carlisle, United Kingdom

Philip Knowles