The Scripps Research Institute

Other

Janssen Pharmaceutica Nv

Paul R Russell

Michael N Boddy

Antonia Lopez-Girona

Jorge Eduardo Vialard

Clare H McGowan

Paul A Shanahan

Cecile-Marie D D Denis

Beth Furnari

Toby L Baumgartner

Alysn Hassenforder

Xiao-Bo Chen

Veronique Blais

Pierre-Henri L Gaillard

The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, proteins encoded thereby, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, and methods for treating a cell using such nucleic acids or proteins.

Human and murine Mus81 proteins

Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be tested with a biochemical mixture containing an isolated mammalian Mus81-Eme1 endonuclease complex, a source of magnesium ion, and a suitable DNA substrate; measuring the activity level of mammalian Mus81-Eme endonuclease complex in the mixture; comparing the measured activity level to the activity level of a substantially similar mixture of isolated Mus81-Eme1 endonuclease, magnesium ion, and DNA substrate in the absence of the chemical compound to be tested; and selecting a chemical compound that increases or decreases the endonuclease activity. Isolated mammalian Eme1 and Eme2 proteins derived from humans and murine species and isolated nucleic acids encoding the proteins are also described.

Mammalian endonucleases and methods of use

The invention describes recombinant fusion proteins containing Wee1 protein sequences involved in checkpoint regulation of cell cycle, nucleic acid molecules that encode the fusion protein, and methods using the proteins for screening for compounds which modulate Wee1 or Cds1 function.

Kinase Wee1 fusion protein compositions, nucleotide sequences, expression systems, and methods of use

The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.

Genes and proteins encoded thereby

A system for moving a pallet is provided. The system provides for a pair of pallets each having means for inducing movement in relation to an other pallet. Further, logic is provided for calculating a movement instruction to move the pallets relative to each other. Additionally, the present invention provides for means for communicating the movement instruction to the movement means on the pallets to prompt movement of one of said pair of pallets relative to the other pallet. As no special floor surface or configuration is necessary, the present invention described herein may be readily adaptable for utilization within existing storage and inventory facilities.

System and apparatus for materials transport and storage

Kinase wee1 fusion protein compositions, nucleotide sequences, expression systems, and methods of use

A multidimensional equilateral angular game playing apparatus and method include electronically controlled, life-sized obelisk 'opponents' in the vertex of each angle. A sound generator and multiple lighted targets are mounted upon variously angled surfaces of each obelisk so that a target becomes momentarily active when its light is illuminated and a sound generator mounted upon the obelisk holding the target is actuated. The sequence of targets presented to a player and the time duration of each activation may be selected in a random manner by electronic controls. A single player strikes activated targets using thrusting and sweeping motions of a double-sided, padded playing staff. Upon successfully striking a target, the sound generator upon which obelisk the target is mounted emits a tone verifying the success of the strike, a point is added to a total sum of successful strikes, the target is deactivated and the next target is immediately presented to the player. Therefore, the speed of the game changes according to the reaction time of each individual player. A score of successful target strikes and total number of targets presented are displayed to the player. Physical agility and stamina, mental concentration and an indomitable spirit are tested and cultivated by the game.

Growing community of inventors

San Diego, CA, United States of America

Paul R Russell