The University of North Carolina at Chapel Hill

Imclone Systems, Inc.

P Frederick Sparling

Nicholas H Carbonetti

Cynthia Nau Cornelissen

Stuart Thompson

Margaret Beucher

Iron-regulated, outer membrane proteins found inandare important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in

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An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.

Antigenic iron repressible proteins from N. meningitidis related to the hemolysin family of toxins

The present invention relates to a gene sequence coding for hybrid Protein I of and cloning vector and host organisms containing same. Also disclosed are oligonucleotides useful as diagnostic probes for the detection of infection.

DNA molecule encoding gonorrhoeal hybrid PIA/PIB protein

The present invention provides an isolated nucleic acid molecule that encodes an amino acid sequence comprising a FrpB protein. The invention also provides vaccine compositions capable of protecting a mammal against infection by,or,comprising the FrpB protein encoded by the isolated nucleic acid of the invention and a pharmaceutically acceptable carrier.

Isolated FrpB nucleic acid molecule

An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.

Antigenic iron repressible protein from N. meningitidis related to the

The present invention relates to a gene sequence coding for Protein I of Neisseria gonorrhoeae, and cloning vector and host organisms containing same. Also disclosed are oligonucleotides useful as diagnostic probes for the detection of N. gonorrhoeae infection.

Production of gonorrheal PI proteins and vaccines

Iron-regulated, outer membrane proteins found in Neisseria gonorrhoeae and Neisseria meningitidis are important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in Neisseria gonorrhoeae.

Isolated nucleic acid molecules encoding transferrin binding proteins

The present invention relates to a gene sequence coding for Protein I of Neisseria gonorrhoea, and cloning vector and host organisms containing same. Also disclosed are oligonucleotides useful as diagnostic probes for the detection of N. gonorrhoea infection.

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Moncure, NC, United States of America

P Frederick Sparling