Antyra Inc.

Novo Nordisk A/s

Olga Dedova

Neil I Goldstein

Arthur J Blume

Renee Brissette

Renuka Pillutla

Ku-chuan Hsiao

Hao Liu

Paul Fletcher

Michael Spruyt

John Prendergast

Pinger Wang

Michael Lennick

Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.

Insulin and IGF-1 receptor agonists and antagonists

The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.

Target specific screening and its use for identifying target binders

Growing community of inventors

Highland Park, NJ, United States of America

Olga Dedova