Howard University

Other

Oladapo Bakare

Samuel Ray Denmeade

Emmanuel S Akinboye

Yakini Brandy

Clarence M Lee

Mozna Husein Khraiwesh

Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2'-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

Emetine derivatives, prodrugs containing same, and methods of treating conditions using same

Methods are provided to inhibit proliferation ofwith imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against Chagas disease.

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Beltsville, MD, United States of America

Oladapo Bakare