The University of Tokyo

Mochida Pharmaceutical Co., Ltd.

Norihiro Kokudo

Satoshi Shimizu

Mitsuko Isaji

Seiichi Ohta

Taichi Ito

Tetsuo Nagano

Yasuteru Urano

Mako Kamiya

Atsushi Miyajima

Masayo Sakabe

Takeaki Ishizawa

Hirohide Yoshikawa

Suguru Yamashita

Natsuko Inagaki

Fuyuki Inagaki

Yuko Shikauchi

Yacko Murase

An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

Adhesion-preventing composition

[Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded. [Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; Rrepresents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R, R, R, R, R, and Reach independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; Rand Reach independently represent a hydrogen atom or an alkyl group; and X represents a C-Calkylene group).

Fluorescent probe for high-sensitivity pancreatic fluid detection, and method for detecting pancreatic fluid

Growing community of inventors

Tokyo, Japan

Norihiro Kokudo