Rhone-Poulenc Agrochimie

Rhone-Poulenc Sante

Noel Rouy

Francois Dewilde

Michel Mulhauser

Viviane Massonneau

Georges Gros

Claude Bonnamas

A stable composition containing 35 to 48% lysine sulphate for animal nutrition is prepared by culturing a lysine-producing microorganism in a culture medium and adding sulfuric acid or ammonium sulphate during culturing to convert lysine as it is formed to lysine sulphate. The culture medium contains ammonia and ammonium sulphate, and a carbon source selected from glucose, sucrose and starch hydrolyzates in an amount such that the total weight ratio of fermentable substances/solids is greater than 80%. The concentration of the carbon source is maintained at 5 to 15 g/liter and ammonia is added during culturing to maintain an ammonium ion concentration of 1 to 5 g/liter. After allowing concentration of the carbon source to fall to less than 2 g/liter, culturing is stopped and the resultant cultured medium is concentrated and dried. The composition has good stability in moist air and preferably has a microporosity of about 0.3 cm.sup.3 /g and a surface area of about 0.5 m.sup.2 /g.

Fermentation process for producing lysine sulphate for animal nutrition

Process for preparing 1-alkyl-5-nitroimidazoles of formula: ##STR1## which comprises reacting an alkyl sulphate with an imidazole derivative of general formula: ##STR2## in an organic solvent, and then hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), R denotes hydrogen, unsubstituted or substituted alkyl, aryl or cycloalkyl. In the formula (I), R.sub.1 denotes alkyl. In the formula (II), X denotes a group which can be removed by hydrolysis or alcoholysis.

Process for preparing 1-alkyl-5-nitroimidazoles

Process for the preparation of optionally hydroxymethylated 6-chlorobenzoxazolone, which consists in chlorinating and, if appropriate, hydroxymethylating benzoxazolone in a mixture of water and dioxane.

Process for the preparation of 3-hydroxymethyl-6-chlorobenzoxazolone

Process for the preparation of optionally hydroxymethylated 6-chlorobenzoxazolone, which consists in chlorinating and, if appropriate, hydroxymethylating benzoxazolone in a mixture of water+dioxane.

Process for the preparation of chlorinated derivatives of benzoxazolones

Process for the preparation of malathion by reacting O,O-dimethyl-dithiophosphoric acid with ethyl maleate in the presence of a solvent which forms a heterogeneous azeotrope with the O,O-dimethyl-dithiophosphoric acid.

Process for the preparation of malathion

Benzoxazolone is prepared by reacting salicylamide with an alkali metal hypochlorite in an aqueous reaction medium comprising an alkali metal hydroxide, the alkali metals comprising said hypochlorite and said hydroxide necessarily including both sodium ions and potassium ions.

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Yerres, France

Noel Rouy