E. R. Squibb Sons, Inc.

Other

Nicholas I Payne

Peter Timmins

Cheryl V Ambrose

J Roger Salmon

A steroid cream formulation which has enhanced physical and chemical stability is formed of (11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy-17-(m ethylthio)androsta-1,4-dien-3-one (tipredane), and a vehicle containing as major ingredients propylene glycol and water together with a sodium citrate or potassium citrate buffer to impart an acid value to the cream formulation of greater than 3, a high melting point wax, such as white wax, to impart proper consistency without adversely affecting stability of the tipredane, benzyl alcohol as a preservative, together with one or more emulsifiers, which include glyceryl stearate, one or more emollients which include isopropyl isostearate or isopropyl palmitate, lubricants and other conventional cream formulation ingredients.

Steroid cream formulation

A method is provided for preparing a stable liposome precursor in the form of a mixture of spray-dried liposomal components including one or more biologically active compounds which may be stored dry and reconstituted with water to form a liposomal preparation immediately prior to use. The dry liposome precursor is also provided.

Spray-drying method for preparing liposomes and products produced thereby

A method is provided for preparing stable liposome precursors in the form of a water-soluble carrier material coated with a predetermined amount of a thin film of liposome components, which method includes the steps of dissolving at least one liposome-forming amphipathic lipid, optionally, at least one biologically active compound, and, optionally, at least one adjuvant in a suitable organic solvent and employing the resulting organic solution to coat a suitable water-soluble carrier material to form thin film of predetermined amount of liposome components thereon. Upon exposing the coated carrier material to water, the thin films of liposome components hydrate and the carrier material dissolves to give liposome preparations.

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Merseyside, United Kingdom

Nicholas I Payne