University of Georgia Research Foundation, Inc.

Amgen Inc.

University of Miami

Nevis L Fregien

Beverly S Adler

Mohamed G Shoreibah

James Michael Pierce

J Michael Pierce

Coralie A Carothers Carraway

Kermit L Carraway

The present invention provides substantially purified UDP-N-acetylglucosamine: .alpha.-6-D-mannoside .beta.-1,6-N-acetylglucosaminyl transferase (GlcNAc T-V; EC 2.4.1.155) proteins and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by GlcNAc T-V coding sequences from rat, hamster, mouse and human.

N-acetylglucosaminyltransferase V proteins and coding sequences

The present invention relates, in general, to a glycoprotein that is a member of the epidermal growth factor superfamily ASGP-2. In particular, the present invention relates to a DNA segment encoding the glycoprotein; to a recombinant DNA molecule containing the DNA segment; to cells containing the recombinant DNA molecule; to a method of producing the glycoprotein; and to methods of disease diagnosis and therapy that involve the use of the glycoprotein or DNA segment encoding same.

Transmembrane glycoprotein ASGP-2: nucleotide sequences and recombinant

The present invention provides a substantially purified UDP-N-acetylglucosamine:.alpha.-6-D-mannoside .beta.-1,6-N-acetylglucosaminyltransferase (GlcNAc T-V; EC 2.4.1.155) and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by a GlcNAc T-V coding sequence from rat.

N-acetylglucosaminyltransferase V gene

Growing community of inventors

Miami, FL, United States of America

Nevis L Fregien