Leprino Foods Company

Amgen Inc.

Neill Burt

Richard Kevin Merrill

Ron C Kelly

Jiancai Li

Twinkle R Christian

Marc A Caporini

Mark Cramer

William Trieu

Laura Nicholson

Rizwan Sharnez

Stephen Charles Secrest

Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

Methods directed to crystalline biomolecules

Methods for preparing spray dried lactose are provided. Methods include concentrating an aqueous lactose source, crystallizing at least a portion of the lactose in the concentrated lactose source, and forming a crystallized lactose slurry comprising a plurality of lactose particles. Methods include washing the crystallized lactose slurry for a period of time sufficient to reduce an absolute value of a b*-value color of the lactose particles by greater than or about 75%. Methods include wet milling the crystallized lactose slurry, reducing a D50 particle size of the plurality of lactose particles by greater than or about 50%. Methods include spray drying the crystallized lactose slurry, forming a plurality of spray dried lactose particles.

One pass spray dried lactose

Methods of making a powdered milk product as described. The methods may include providing an aqueous milk-sourced mixture, and evaporating water from the aqueous milk-sourced mixture to produce an evaporated milk-sourced mixture having a total solids concentration of 35 wt. % or more. The evaporated milk-sourced mixture may be dried to form the powdered milk product, which may have less than 6 wt. % water. Systems for making the milk powdered product are also described. The systems may include an evaporator to evaporate water from a supply of a milk-sourced mixture to form an evaporated milk-sourced mixture. They may also include a dryer to dry the evaporated milk-sourced mixture and atomize it into the powdered milk product.

Tandem evaporation-drying methods and systems for making powdered milkderived products

Methods of making a powdered milk product are described. The methods may include providing an aqueous milk-sourced mixture, and evaporating water from the aqueous milk-sourced mixture to produce an evaporated milk-sourced mixture having a total solids concentration of 35 wt. % or more. The evaporated milk-sourced mixture may be dried to form the powdered milk product, which may have less than 6 wt. % water. Systems for making the milk powdered product are also described. The systems may include an evaporator to evaporate water from a supply of a milk-sourced mixture to form an evaporated milk-sourced mixture. They may also include a dryer to dry the evaporated milk-sourced mixture and atomize it into the powdered milk product.

Tandem evaporation-drying methods and systems for making powdered milk-derived products

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Denver, CO, United States of America

Neill Burt