American Home Products Corporation

Narender K Kalyan

Paul P Hung

Shaw-Guang L Lee

Shawguang L Lee

Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.

Expression of specific immunogens using viral antigens

Des-epidermal growth factor homologous--plasminogen activators with greatly diminished affinity for liver membranes.

Des-epidermal growth factor plasminogen activators

Tris-Kringle plasminogen activators containing an additional second kringle domain or an additional modified second kringle domain are useful in disrupting blood clots.

Tris-Kringle plasminogen activator with novel K2 insert

Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.

Process for treating thrombosis by administering poly-kringle

Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators. Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.

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King of Prussia, PA, United States of America

Narender K Kalyan