Morinaga Milk Industry Co., Ltd.

The Green Cross Corporation

Muneo Yamada

Miyuki Tanaka

Eriko Misawa

Hirotoshi Hayasawa

Yousuke Itou

Noriko Wakimoto

Masanori Inagaki

Ryuuichi Higuchi

Nobuya Yanai

Kouji Nomaguchi

Morio Kuboyama

Noriko Habara

Shinya Suzu

Satoshi Funakoshi

Katsuhiro Ogasa

Fumimaro Takaku

Hajime Yokota

Hiroaki Hageshita

Yousuke Itoh

Nobuhiro Yamada

Masayuki Nishida

Takuji Kawashima

Kazuo Motoyoshi

Kazuo Morimoto

Kunio Ujiie

Katsuo Yoshida

Yoshiteru Watanabe

The present invention provides: anextract that can be safely ingested, can be used as a material of food for preventing lifestyle diseases, contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods; and a method of producing theextract. A supercritical fluid extraction method can produce anextract containing a mixture that consists of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more and having the following properties (1) and/or (2):

Method of producing aloe vera extract

Anextract is provided that can be safely ingested and, can be used as a food material for treating lifestyle diseases such as hyperglycemia. Theextract contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods. Theextract is produced by a supercritical fluid extraction method and contains a mixture of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more. The mass mixing ratio of cyclolanostane compound:lophenol compound is 5.1:4.9 to 6.3:2.7 and/or the content of an anthraquinone-based compound is 0.001% by mass or less.

Method for treating hyperglycemia

3-O-&#x3b2;-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.

Glycoside having 4-methylergost-7-en-3-ol skeleton and hyperglycemia improving agent

Compounds having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol are used as an active ingredient of a drug and food or drink for improving pancreatic functions.

Drug and food or drink for improving pancreatic functions

The invention relates to a GLP-1 secretagogue and an inhibitor of postprandial rise in blood glucose, containing &#x3ba;-casein as an active ingredient, and a food or drink for promoting GLP-1 secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein &#x3ba;-casein accounts for 60% by mass or more of the milk-derived casein.

Method for promoting secretion of glucagon-like peptide-1 by administering &#x3ba;-casein

A compound having a hyperglycemia improving effect and a hemoglobin A1c lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.

Drug for improving hyperglycemia

The invention relates to a GLP-secretagogue and an inhibitor of postprandial rise in blood glucose, containing &#x3ba;-casein as an active ingredient, and a food or drink for promoting GLP-secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein &#x3ba;-casein accounts for 60% by mass or more of the milk-derived casein.

Method for inhibiting postprandial rise in blood glucose by administering &#x3ba;-casein

Compounds such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol which have an activity for improving pancreatic function are used as an active ingredient of a pancreas function improving drug and food or drink.

Method for improving pancreatic functions

A compound having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.

Drug and food or drink for improving hyperglycemia

3-O-&#x3b2;-D-Glucopyranosyl-4-methyl-ergost-7-en-3-ol or a composition containing 0.001 to 10% by dry mass of the aforementioned compound, which is an extract of a plant of the family Liliaceae or a fraction thereof containing the compound, is used as an active ingredient of a drug for improving pancreatic functions.

Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof:

Method for diagnosing aplasia of corpus callosum

Gene useful for diagnosis and treatment of aplasia of corpus callosum and aspermatogenesis and use thereof

Human M-CSF preparations and recombinant human M-CSF preparations against myelodysplastic syndrome, malignant tumor and hyperlipemia and auxiliary therapeutic preparations to be dosed along with platinum-complex anticancer preparations.

Growing community of inventors

Zama, Japan

Muneo Yamada