Tate & Lyle Technology Limited

Mohamad R Jaber

James Edwin Wiley, Jr

David A Dentel

Wayne N Boutzale

A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used as a reaction vehicle for the chlorination of sucrose-6-acylates, thereby improving the yields of the desired sucralose-6-acylate (an intermediate in the production of sucralose).

Purification of tertiary formamide contaminated with tertiary acetamide

A method for the chlorination of a sucrose-6-acylate to produce a 4,1',6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy-galactosucrose-&#x3b2;-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide in order to chlorinate the 4, V and 6&#x2032; positions of the sucrose-6-acylate; and (ii) quenching the product stream of (i) to produce a 4,1&#x2032;,6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of the tertiary amide is removed.

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Rancho Cucamonga, CA, United States of America

Mohamad R Jaber