National Cheng-Kung University

Amgen Inc.

Lbl Biotechnology, Inc.

Chi Mei Medical Center

Yung Shin Pharmaceutical Industrial Co. Ltd.

Chang, Ming-Shi

Ming-Shi Chang

William James Boyle

Frank J Calzone

David L Lacey

Naoya Tsurushita

Shankar Kumar

Christiaan M Saris

Meng-Ru Shen

Chris Saris

I-Ming Jou

Yu-Hsiang Hsu

Yen-Chen Liu

Methods of treating tissue fibrosis and/or injury and/or organ failure using an interleukin 24 (IL-24) protein or an interleukin 20 (IL-20) antagonist are provided.

Treating tissue fibrosis with interleukin 24

Methods and compositions relating to combination therapy using an IL-20 antagonist and an immune checkpoint inhibitor are provided.

Combination therapy using an IL-20 antagonist and an immune checkpoint inhibitor

Methods for treating eye diseases such as dry eye disease (DED) and age-related macular degeneration (AMD) using an IL-20 antagonist that blocks the signaling pathway mediated by IL-20, for example, an antibody that binds IL-20 or an IL-20 receptor.

Use of IL-20 antagonists for treating eye diseases

Methods for treating pancreatic cancer using an IL-20 antagonist, which can be an antibody that binds IL-20 or an IL-20 receptor, thereby blocking the signaling pathway mediated by IL-20.

Use of IL-20 antagonists for treating pancreatic cancer

Disclosed herein are antibodies capable of inhibiting canine vascular endothelial growth factor and uses thereof in treating a canine angiogenesis-related disorder such as a proliferative disease.

Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof

Alleviating obesity in a subject (e.g., a human subject) having, obesity using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.

Method of inhibiting adipogenesis with an IL-20 antibody

Humanized antibodies specific to human interleukin 20 (IL-20) and uses thereof in treating diseases associated with the IL-20 signaling pathway, e.g., osteoporosis, inflammatory disease (e.g., rheumatoid arthritis), cancer, stroke, and renal failure.

Humanized anti-IL-20 antibody and uses thereof

Alleviating neural injury, such as spinal cord injury, in a subject (e.g., a human subject) in need of the treatment using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.

Use of IL-20 antagonists for alleviating spinal cord injury

Reducing inflammatory pain in a subject having or being suspected of having an inflammatory pain using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.

Treatment of inflammatory pain using IL-20 antagonists

Reducing liver fibrosis in a subject having or being suspected of having a liver disease using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.

Use of IL-20 antagonists for treating liver diseases

The present disclosure provides methods for alleviating or delaying the onset of osteoarthritis in a subject in need of the treatment using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20, e.g., an anti-IL-20 antibody.

Treatment of osteoarthritis using IL-20 antagonists

The present disclosure provides humanized antibodies specific to human interleukin 20 (IL-20) and uses thereof in treating diseases associated with the IL-20 signaling pathway, e.g., osteoporosis, inflammatory disease (e.g., rheumatoid arthritis), cancer, stroke, and renal failure.

Treating a disorder (e.g., osteoporosis, renal failure, or diabetic nephropathy) associated with a signaling pathway mediated by IL-20 receptor with an agent that suppresses IL-20 receptor activity, e.g., an antibody that neutralizes IL-20 receptor via binding to IL-20R1, an antisense nucleic acid that suppresses expression of IL-20R1, a small molecule that inhibits IL-20 receptor activity, or a dominant negative mutant of IL-19, IL-20, or IL-24.

Methods for treating osteoporosis with anti-IL-20 receptor antibodies

The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.

Methods of using antibodies to block human thymic stromal lymphopoietin (TSLP) receptor activity

Treatment of an allergic airway disorder (e.g., asthma or bronchial airway obstruction) using anti-IL-20R1 antibodies such as mAb51D, mAb7GW, or functional variants thereof.

Growing community of inventors

Tainan, Taiwan

Ming-Shi Chang