Shionogi Company Limited

Mikao Mayama

Kouichi Matsumoto

Shinzo Matsuura

Naoki Tsuji

Yoshimi Kawamura

Eiji Kondo

Kentaro Tanaka

Jun'ichi Shoji

Yoshiharu Wakisaka

Kei Okabe

New antibiotics having .beta.-lactamase inhibitory activity, PA-41746-B and C of the formula ##STR1## wherein R is carboxymethylsulfinyl (PA-41746-B) or formylsulfinyl (PA-41746-C) and the pharmaceutically acceptable salts being useful as a medicament, a veterinary drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces pluracidomyceticus in a suitable medium and isolating PA-41746-B and/or PA-41746-C from the culture broth.

Antibiotics PA-41746-B and C

Antibiotic siomycin A derivatives produced by reaction of siomycin A with a dicarboxylic acid. The compounds have excellent characteristics, particularly in their solubility in comparison with that of siomycin A, and are useful as medicaments.

Antibiotic siomycin A derivatives and production thereof

A new antibiotic, 342-14-I, bein useful as a medicament and veterinary drug for inhibiting the growth of gram-positive pathogenic microorganism, and a process for preparing the same, being characterized by cultivating a 342-14-I-producing strain of microorganism belonging to the Genus Bacillus in an aqueous nutrient medium under aerobic conditions.

Antibiotic 342-14-I and production thereof

Growing community of inventors

Ikeda, Japan

Mikao Mayama