Yale University

Universidad Complutense De Madrid

Miguel A Alonso

Sherman M Weissman

Carmen Avendano

Blanca Ocana

Jose C Mendendez

Dolores Garcia-Gravalos

Jose M Perez

Modesta Espada

Azaanthracene-triones of the formula: ##STR1## (in which: R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are the same or are different and each is a hydrogen atom or a lower alkyl group;

Antitumoral compounds

A 16.7 kilodalton membrane protein which is produced in mature, but no early-stage, T cells has been discovered. The protein has four distinct amphipathic domains, each having an amino acid composition which is predictive of an alpha helical structure that would be stable in a lipid bilayer. Each of these regions is flanked by a relatively polar domain whose amino acid sequence is predictive of .beta. pleat peptide regions. An antibody specific against one of the polar domains can be used to discriminate mature T-cells in a mixed-cell sample.

T-cell membrane protein

Growing community of inventors

Madrid, Spain

Miguel A Alonso