Smithkline-rit

Michele Lobmann

Gerard Florent

Nathan Zygraich

Jean-Claude Delgoffe

Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.

Temperature sensitive strain of bovine viral diarrhoea virus

A live bovine viral diarrhoea (BVD) virus vaccine capable of producing immunity in bovines without causing significant side effects comprising a temperature sensitive (ts) mutant of BVD virus which is obtained by mutating a strain of BVD virus with nitrous acid. The temperature sensitive mutants show a replication ability considerably limited at the animal body temperature of 39.5.degree. C. The vaccine may be combined with other live bovine vaccines such as respiratory virus vaccines and then administered to bovines.

Temperature sensitive strains of bovine viral diarrhoea virus,

The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain. The new strain, which is the CNCM N.degree. I-099 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/California/10/78 (CNCM N.degree. I-098) virus strain. The vaccine is prepared by allowing the CNCM N.degree. I-099 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material. The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.1 N.sub.1) virus strains.

Influenza virus and process of producing a vaccine therefrom

The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain. The new strain, which is the CNCM I-062 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/Alaska/5/77 virus strain. The vaccine is prepared by allowing the CNCM I-062 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material. The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.3 N.sub.2) virus strains.

Live influenza virus vaccine and the preparation thereof

The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain. The new strain, which is the DNCM No. I-099 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/California/10/78 (CNCM No. I-098) virus strain. The vaccine is prepared by allowing the CNCM No. I-099 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material. The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.1 N.sub.1) virus strains.

Growing community of inventors

Bierges, Belgium

Michele Lobmann