Wisconsin Alumni Research Foundation

Michael W Pariza

Mark Eric Cook

Yeonhwa Park

Daria L Jerome

Danielle DeVoney

Xiaoyun Yang

Yeong L Ha

Kisun N Lee

Dennis R Buege

Xiao-Yun Yang

Daria Jerome

Bernard C Wentworth

Leah D Whigham

Rahim Aydin

Ellen B Cook

Tilak R Dhiman

Paul Mozdziak

Larry D Satter

Guangming Li

Sohee Kim

Richard L Atkinson, Jr

Ming-der Yang

Frank M Graziano

James L Stahl

A method for controlling body fat in a human or nonhuman animal includes the step of reducing lipoxygenase activity in an animal. Lipoxygenase activity can be reduced by reducing the enzyme activity or by lowering the enzyme level. Reduced lipoxygenase activity correlates with reduced cell-associated LPL activity and with reduced cellular triacylglyceride level.

Animal body fat control

The present invention provides a method of using conjugated nonadecadienoic acid (CNA), one of its derivatives, or a combination thereof to inhibit lipoprotein lipase activity associated with a cell, to control body fat in a human or non-human animal, to inhibit cyclooxygenase activity in a cell, to inhibit platelet aggregation in a human or non-human animal, and to prevent or treat a condition or disease related to platelet aggregation.

Conjugated nonadecadienoic acid compositions

A method for reducing certain effects associated with a negative calorie balance in a human includes the step of administering conjugated linoleic acid to a human in an amount effective to reduce at least one of the effects.

Method for reducing adverse effects of a weight loss regimen

Administering conjugated linoleic acid to human and non-human animals having conditions associated with the existence of autoimmune complexes or auto-immune reactive cells can extend the survival life time, prolong healthy tissue and organ function and prevent body weight wasting in these animals.

Method of increasing longevity and preventing body weight wasting in autoimmune disease by using conjugated linoleic acid

An egg enriched for conjugated linoleic acid and having a normal appearance is produced by feeding poultry a diet enriched in conjugated linoleic acid (CLA) and a selected monounsaturated fatty acid. A poultry feed supplemented having conjugated linoleic acid and a selected monounsaturated fatty acid.

Eggs enriched with conjugated linoleic acid

Disclosed is a method for selectively inhibiting cyclooxygenase-2 in an animal having a cyclooxygenase-2 activity by delivering into the animal an amount of a conjugated linoleic acid effective to reduce cyclooxygenase-2 activity in the animal.

Selective inhibition of cyclooxygenase-2

A method of treating meat animals to increase fat firmness, shelf life and meat quality indices consisting of administering to the meat animals a safe and effective amount of conjugated linoleic acid or CLA.

Method of increasing fat firmness and improving meat quality in animals

A method for producing a cis-9, trans-11 fatty acid from a fatty acid containing double bonds in the cis-configuration at positions 9 and 12, includes the step of combining a Lactobacillus microorganism with free fatty acids in a fermentation process. The conjugated fatty acid products can include, for example, cis-9, trans-11 conjugated linoleic acid (CLA).

Method of producing conjugated fatty acids

A method for treating an animal to reduce body fat while the animal exhibits improved feed efficiency and either continued weight gain or an increase in lean body mass includes the steps of administering to the animal a combination of CLA isomers in a ratio selected to retain a desirable benefit attributable to one isomer while counteracting an undesirable effect of the same isomer.

Method for selectively altering body fat level, feed efficiently, or

Methods of treating animals to maintain or elevate CD-4 and CD-8 cell levels and to prevent or alleviate the adverse effects on the animal caused by the production or exogenous administration of tumor necrosis factor (TNF) or by a virus consist of administering to the animal a safe and effective amount of a conjugated linoleic acid (CLA) or a substance which is converted in the animal into CLA. A method of preparing CLA employing a bacteria isolated from a rat colon also is disclosed.

Methods of treating animals to maintain or increase CD-4 and CD-8 cell

A method of enhancing the activity of natural killer lymphocytes and a method for increasing the basal level of natural killer activity in an animal include the step of administering orally or parenterally to said animal a safe amount of CLA, said amount being effective to enhance the activity of killer lymphocytes or to enhance the basal activity of killer lymphocytes in the animal.

Methods of treating animals to enhance natural killer lymphocyte function

Methods of inhibiting lipoprotein lipase and controlling the body fat and the body weight of an animal employ an effective amount of at least one 20 carbon, conjugated, unsaturated, fatty acid. Pharmaceutical compositions for use in the method are also disclosed. The 20-carbon conjugated fatty acids are selected from an eicosadienoic acid, an eicosatrienoic acid, and an eicosatetraenoic acid. Preferably, the fatty acids are 11,13-eicosadienoic acid; 12,14-eicosadienoic acid; 8,11,13-eicosatrienoic acid; 5,8,11,13-eicosatetraenoic acid; 5,8,12,14-eicosatetraenoic acid, or an ester, salt, or mixture thereof.

Method for controlling body fat and/or body weight in animals and

A method of treating meat animals to increase fat firmness and meat quality indices which increases meat processability consists of administering to the meat animals a safe and effective amount of conjugated linoleic acid or CLA.

A method of reducing apolipoprotein B secretion comprises making available to animal cells an amount of conjugated linoleic acid effective to reduce apolipoprotein B secretion from the cells. A related method comprises administering to an animal a safe and effective amount of a conjugated linoleic acid to reduce apolipoprotein B secretion into the animal's bloodstream.

Growing community of inventors

Madison, WI, United States of America

Michael W Pariza