Immunogen, Inc.

Jervis B. Webb Company

Daifuku Co., Ltd.

Tufts University

Jervis B. Webb International Company

Michael S Fleming

Godfrey W Amphlett

Wei Zhang

Christopher John Murphy

David R Walt

Christopher B Murphy

Benjamin M Hutchins

Nicholas C Yoder

Hung-wei Chih

Elizabeth Bartlett

Robertus A Schmit

Todd Alderman

Chen Bai

Godfrey Amphlett

Hung-Wei Chih

Tarun K Mandal

Scott Alan Hilderbrand

Amit Gangar

A system and method for storing and sequencing a plurality of luggage items. The system includes containers with vertically stacked shelves and an automatic guided vehicle releasably attachable to the containers for transporting a container between a first predetermined area and a loading area with a loading assembly to move a luggage item from an entrance conveyor onto one of the shelves of the container. The containers may include wheels for being manually moved. A transport vehicle is provided for moving a plurality of containers together. The method includes determining a grouping criterion of the luggage item and sorting and sequencing luggage items onto containers according to the grouping criterion. Different embodiments of the loading assembly are provided with one using a packing automated vehicle and another using stacked platform conveyors. Several grouping criteria are provided which may depend on processing requirements of the luggage items.

System and method for storing and sequencing luggage items

A system and method of operating a checked bag reconciliation area of an airport. The method includes transporting a luggage item from an entrance mechanism to one of a plurality of inspection stations. Once the luggage item is at the inspection station, the method proceeds by conducting an inspection of the luggage item by the agent at the inspection station. The step of transporting the luggage item includes transporting the luggage item to the inspection station with the luggage item disposed on an automatic material handling device, and the step of conducting an inspection of the luggage item by the agent includes conducting the inspection of the luggage item while the luggage item is disposed on the automatic material handling device.

Method and system for automated luggage security inspection

The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.

Immunoconjugate formulations

The invention provides a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human the reconstituted composition such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

Drug conjugate composition

The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

Polymeric microspheres

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Londonderry, NH, United States of America

Michael S Fleming