Competitive Technologies, Inc.

Yale University

Innovir Laboratories, Inc.

Competitve Technologies, Inc.

Michael Ma

Marvin H Caruthers

Wolfgang K-d Brill

Eric K Yau

John Nielsen

Shaji T George

Allan R Goldberg

Martina Werner

Umberto Pace

Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.

Stabilized external guide sequences

The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.

Polynucleotide phosphorodithioate compounds

EGS-mediated inactivation of target RNA

Nucleoside thiophosphoramidites

Dinucleoside phosphorodithioate phosphoramidite precursors useful in the synthesis of oligonucleotide phosphorodithioate which can be used as antisense inhibitors of translation.

Growing community of inventors

New York, NY, United States of America

Michael Ma