B.r.a.i.n. Biotechnology Research and Information Network Ag

Basf Se Corporation

Symrise Ag

Nutrinova Nutrition Specialties & Food Ingredients Gmbh

Brain Ag

Merck Patent Gmbh

General Mills, Inc.

Analyticon Discovery Gmbh

Brain Corporation

Brain Biotech Ag

Michael Krohn

Holger Zinke

Andreas Hochheimer

Thomas Subkowski

Claus Bollschweiler

Jürgen Eck

Jens Wittenberg

Frank Niehaus

Karsten Siems

Renate Schulze

Dirk Sombroek

Bernhard H Van Lengerich

Walter Kuhn

Heiko Oertling

Christine M Nowakowski

Christophe Carola

Erich Dilk

Gabriele Vielhaber

Ingo Wöhrle

Joachim Hans

Lars Ole Haustedt

Amandine Druon

Claudia Gömann

Andreas Ernst

Antje Köhler

Hansjuergen Driller

Christian Köpsel

Yvonne Tiffert

Grit Kluge

Olaf Gruess

Gregor Hetterling

Christian Ewering

Julian Osthoff

Torsten Ertongur-Fauth

Lia Scarabottolo

Candace Michelle Rathjen-Nowak

Suzanne Denise Pecore

Jens-Peter Muller

Christian Zurek

Alice Kleber

Pul Ümit

Markus Matuschek

Jörg Mampel

Johann Wonschik

Loïc Briand

Katja Riedel

Fotini Tsichrintzi

Robin Back

Antje Pfeiffer

Stephanie Grond

Martin B Jager

Ute Dechert

Oliver Schwarz

Jens-Peter MÜLLER

Claudia GÖMANN

Ingo WÖHRLE

Berhard H Van Lengerich

Nicolas Descamps

Kerstin Rudert

Fabrice Neiers

Christian Naumer

Simon Seibert

Ümit Pul

Paul Scholz

Naturally-derived compounds having various structures elicit the perception of salty taste or enhance the perception of salty taste of a salt. Food products may include such salty compounds, which may be used to reduce the sodium content, while parting a similar level of saltiness.

Reduced sodium food products

Suggested is a method for enhancing the expression of taste related receptor genes encompassing the following steps: (i) providing a culture of mammalian cells, the genome of said cells comprising at least one sweet receptor domain; (ii) designing at least one type of single-guide RNA (sgRNA), the 10 to 30 nt guide sequence of said sgRNA being complementary to stretches within the non-coding and/or putative regulatory region upstream of the translation start codon of at least one sweet receptor gene; (iii) preparing a vector comprising an expression cassette encompassing at least one optionally modified CRISPR-Cas9, preferably CRISPR-dCas9VP64, and at least one optionally modified sg-RNA optionally containing aptamer structures for binding activator proteins; (iv) transfecting said culture of mammalian cells with said vector to target the genome for the presence of a DNA sequence that is complementary to the 10 to 30 nt guide sequence of said sgRNA; and (v) measuring the transcriptional enhancement of the sweet receptor mRNA by quantitative RT-PCR.

Activation of taste receptor genes in mammalian cells using CRISPR-Cas-9

The present invention relates to the use of monosubstiuted urea derivatives of the formula I as self-tanning substance, for increasing melanin synthesis, for improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these urea derivatives.

Monosubstituted urea derivatives as a self-tanning substance

Suggested are preparations, comprising or consisting of

Method for masking unpleasant taste

We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80% identical to the amino acid sequence of (a), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80% identical to the nucleotide sequence of (b), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.

Protease for wound conditioning and skin care

The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.

Small molecule inhibitors of TRPA1

Accordingly, the present invention relates to a nucleic acid molecule encoding a protein capable of forming a calcium-activated chloride channel, wherein said nucleic acid molecule comprises or consists of (a) a nucleic acid molecule encoding a protein having the amino acid sequence of SEQ ID NO:1; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO:2; (c) a nucleic acid molecule having the sequence of SEQ ID NO:2, wherein each thymine is replaced by uracil; (d) a nucleic acid molecule that hybridizes under stringent conditions to the complementary strand of a nucleic acid molecule of (a), (b) or (c); (e) a nucleic acid molecule encoding a protein having at least 97% sequence identity to the protein of (a); or (f) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b), (c) or (d). The present invention further relates to a protein capable of forming a calcium-activated chloride channel, the use of the nucleic acid molecule of or the protein of the invention for identifying an inhibitor of sweat formation as well as an in vitro method of identifying an inhibitor of sweat formation.

Calcium-activated chloride channel involved in human sweat formation

The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body. In particular, the present invention relates to the use of compounds modulating TRPM8, and optionally to the use of compounds selectively exhibiting agonist activity at the TRPM8 channel. Such compounds have applications in many fields, particularly in oral and personal hygiene products and foodstuffs, but also in pharmaceutical composition products, cosmetics, textile products and packaging products. The present invention further relates to products containing such compounds and to the medical use of such compounds.

Small molecule modulators of the cold and menthol receptor TRPM8

The present invention relates to proliferating human taste cells, wherein the cells are the cells deposited under the DSMZ deposit accession number DSM ACC3169 or taste cells derived thereof. The present invention further relates to the proliferating human taste cells of the invention for use in research. Further, the present invention relates to in vitro methods for analyzing the signalling response of taste cells to a molecule involved in taste signalling, in vitro methods of identifying agents capable of eliciting a taste response in taste cells as well as in vitro methods of identifying modulators of taste signalling.

Human taste cells capable of continuous proliferation

The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold sensation; and to objects and means produced using said modulators.

Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8

The present invention primarily relates to the use of trans-tert-butyl cyclohexanol as skin irritation-reducing agent as well as compositions (formulations) having a skin irritation-reducing action comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent.

Compositions comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent

The present invention relates to antimicrobially active &#x3c9;-cyclohexylalkan-1-oles of the following formula (I), to a method for producing said compounds and to the use thereof as antimicrobial agents for treating body odor, whereinRto Rindependently of one another denote hydrogen or a linear or branched alkyl radical having 1 to 12 carbon atoms,Rand Rindependently of one another denote hydrogen, a linear or branched alkyl radical having 1 to 6 carbon atoms or a linear or branched alkoxy radical having 1 to 4 carbon atoms, andx is 0 or 1,wherein preferably the total number of carbon atoms in Rto Ris 18 or less.

Omega-cyclohexylalkan-1-oles and use thereof as antimicrobial actives to combat body odor

We have identified by molecular cloning a protease which originates from the larvae ofand which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80% identical to the amino acid sequence of (a), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80% identical to the nucleotide sequence of (b), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.

Growing community of inventors

Lorsch, Germany

Michael Krohn