University of Southern California

Cocensys Inc.

Purdue Pharma L.p.

Michael B Bolger

Nancy C Lan

Derk J Hogenkamp

Kelvin W Gee

Seid Mirsadeghi

Delia Belelli

Bruce S McEwen

Robert Purdy

Deborah J Burke

Hasan Tahir

Richard Gabriel

Jay Stearns

Richard Buswell

Syed Hasan Tahir

Roberta E Brinton

Robert H Purdy

Ravindra B Upasani

Nancy Tsai-Yun Lan

Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.

Methods, compositions, and compounds for allosteric modulation of the

This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3.alpha.-hydroxy,3.beta.-substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectively into a 3(R)-pregnan-3-spiro-2'oxirane-20-one intermediate. This intermediate can then be converted regioselectively by a second set of reactions to the 3.alpha.-hydroxy,3.beta.-substituted-20-one form, which can be further modified at the 20-keto position. Through this method, each ketone group is independently treated. By modifying the ketones one at a time, one can obtain the desired stereo-specificity at each site.

Method for making 3.alpha.-hydroxy, 3.beta.-substituted-pregnanes

Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionophore (GBR) complex.

Method, compositions, and compounds for modulating brain excitability

Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.

Growing community of inventors

Los Alamitos, CA, United States of America

Michael B Bolger