Basf Se Corporation

Organobalance Gmbh

Mewes Böttner

Christine Lang

Markus Veen

Andreas Raab

Andreas Reindl

Bruno Kaesler

Rolf Knöll

Michael Schilling

Eckhard Budde

Martin Ryser

Andreas Heilmann

The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in the absence of the cultivation additive. The genes that are part of the group comprising 'PYC1, ACS1, CIT1, ACO1, ICL1, MSL1, and CIT2, optionally also MDH3' are constitutively active. The invention further relates to uses of such a microorganism, especially for producing succinic acid.

Microorganism for the production of succinic acid

Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth ofbut does not stimulate the growth ofand/or. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.

Use and methods for preventing and/or treating oral malodour

Growing community of inventors

Berlin, Germany

Mewes Böttner