Baxter International Inc.

Melaine Alpern

Cataline M Garanchon

Shu Len Liu

William R Thomas

Samia S Mankarious

Stanley T Enomoto

Daphne C Tse

Michael J Griffith

Joyce E Lawrence

A method for preparing a fibrinogen-containing composition derived from human plasma by separating a cryoprecipitate from the plasma, suspending the cryoprecipitate in a salt-containing buffer, treating the supernatant by affinity-chromatography on a lysine-bound solid matrix to allow plasminogen to adsorb thereon, collecting a fraction containing less than 10 .mu.g/ml plasminogen, and treating the fraction to reduce viral activity. The fibrinogen-containing composition recovered from this fraction is advantageous because it contains such a low amount of plasminogen that no addition of fibrinolysis inhibitor is needed.

Method of preparing a topical fibrinogen complex

A composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as being free of detectable levels of lipid enveloped virus activity, free of prothrombin complex and active thrombin, and contains no protease inhibitors or other non-human proteins. Also, described is a method for producing the composition.

Topical fibrinogen complex

Pharmaceutical compositions useful for the treatment or prophylaxis of Gram-negative bacteremia or septic shock contain a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The compositions may further contain one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins. A method for the treatment or prophylaxis of Gram-negative bacteremia or septic shock comprises administering, either together or separately, a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The method may optionally include administering one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.

Compositions and method for the treatment or prophylaxis of sepsis or

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Long Beach, CA, United States of America

Melaine Alpern