Food Industry Research and Development Institute

Mei-Li Chao

Wen-Shen Chu

Chiou-Yen Wen

Jen-Tao Chen

Shie-Jea Lin

Min Tseng

Yi-Shin Lin

Chang-Hsiesh Liu

Proteins isolated fromhaving prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.

Protein having prolyl oligopeptidase activity, nucleic acid encoding same and method for producing and using same

A protein of amino acid sequence SEQ ID NO:6 isolated from. The protein is stable at 30 to 37 degrees centigrade and has an optimal prolyl oligopeptidase activity at about 45 degree centigrade and at about pH 7. The present invention also relates to a medicament comprising such protein for treating celiac disease caused by proline abundant gluten.

Protein having prolyl oligopeptidase activity, and composition containing the same

A DNA molecule encoding transglutaminase, a transglutaminase, an expression vector containing the DNA molecule, and a cell containing the expression vector.

Transglutaminase

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Hsinchu, Taiwan

Mei-Li Chao