Commonwealth Scientific and Industrial Research Organisation

Gene Shears Pty. Limited

Maxine June McCall

Philip Hendry

Trevor John Lockett

Philip Anthony Jennings

The invention describes catalytic nucleic acid based compounds capable of cleaving nucleic acid polymers both in vivo and in vitro. Two embodiments of this invention are compounds with a short stem that does not base pair, a minizyme, and compounds with DNA hybridizing arms and RNA catalytic domain and stem, DNA-armed ribozymes. The compounds of this invention, while nucleotide based may be substituted or modified in the sugar, phosphate, or base. Methods of use and methods of treatment are also described.

DNA-Armed ribozymes and minizymes

This invention is directed to improved catalytic compounds, minizymes and miniribozymes, capable of hybridizing with a target RNA to be cleaved. The minizymes and miniribozymes and compositions of the present invention may be used in vitro or in vivo. They may be used as diagnostic or therapeutic agents.

Optimized minizymes and miniribozymes and uses thereof

This invention is directed to a compound having the formula:

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Gladesville, Australia

Maxine June McCall