Dow Agrosciences LLC

Sangamo Therapeutics, Inc.

Corteva Agriscience LLC

Matthew J Henry

Steven Robert Webb

Manju Gupta

German Carlos Spangenberg

John White Forster

Matthew Hayden

Noel Cogan

Tim Sawbridge

Jeffrey C Miller

Dmitry Y Guschin

Chenglin Yao

Kevin Gerald Meyer

Richard Brewer Rogers

Ignacio Mario Larrinua

Bassam S Nader

Robert Peter Gajewski

William Hunter Dent, Iii

John L Miesel

W Michael Ainley

Irene Mae Morrison

Michael John Ricks

Gina Marie Fitzpatrick

Jenifer L Adamski Butz

Kenneth Edwin Narva

Noormohamed Mohamed Niyaz

William M Ainley

Navin Elango

Huarong Li

Monica Britt Olson

Chaoxian Geng

Sandeep Kumar

Aaron Todd Woosley

Stephen N Novak

Gary David Gustafson

Sean Michael Russell

Clive Waldron

George E Davis

Murugesan Rangasamy

John Mason

W Mike Ainley

Amy J Smith

Noormohamad M Niyaz

Irene M Morrison

William H Iii Dent

William Michael Ainley

German Spangenberg

John Forster

Dmitry J Guschin

A method of gene editing or gene stacking within a FAD3 loci by cleaving, in a site directed manner, a location in a FAD3 gene in a cell, to generate a break in the FAD3 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.

FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks

An Engineered Transgene Integration Platform (ETIP) is described that can be inserted randomly or at targeted locations in plant genomes to facilitate rapid selection and detection of a GOI that is perfectly targeted (both the 5' and 3&#x2032; ends) at the ETIP genomic location. One element in the subject disclosure is the introduction of specific double stranded breaks within the ETIP. In some embodiments, an ETIP is described using zinc finger nuclease binding sites, but may utilize other targeting technologies such as meganucleases, CRISPRs, TALs, or leucine zippers. Also described are compositions of, and methods for producing, transgenic plants wherein the donor or payload DNA expresses one or more products of an exogenous nucleic acid sequence (e.g. protein or RNA) that has been stably-integrated into an ETIP in a plant cell. In embodiments, the ETIP facilitates testing of gene candidates and plant expression vectors from ideation through Development phases.

Engineered transgene integration platform (ETIP) for gene targeting and trait stacking

A method of gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a cell, to generate a break in the FAD2 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.

FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks

This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.

Nucleic acid molecules that confer resistance to coleopteran pests

Nucleic acid molecules that target the vacuolar atpase C subunit and confer resistance to coleopteran pests

The subject invention provides novel amino acid sequences (including a consensus sequence) of the Avian Influenza A virus hemagglutinin protein. These newly constructed genes are designed to provide a broader spectrum of activity across the serotype family thus providing a basis for a vaccine that has broad heterologous disease protection. The novel genes have been further improved by the addition of strategic glycosylation sites into the amino acids sequences that they encode. These genes can also, optionally, be codon optimized for plant expression, inserted into the appropriate vector and cloned into plants for expression. Polypeptides produced by recombinant host cells or transgenic plants can also be used as source of antigen for the formulation of vaccines for the control of influenza in susceptible individuals. Additionally, transgenic plant material may also be used as source of antigen for the formulation of vaccines for the control of influenza in susceptible individuals.

DNA sequences, vectors and proteins of avian influenza hemagglutinin

The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HA1 polypeptides having specified homologies that are used to prepare vaccine compositions and methods for inducing protective immunity in an individual, animal, mammal or human.

Vaccine for avian influenza and methods of use

A compound having the following formula:wherein Rand M are defined herein, and processes therewith.

Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation

Dihydroorotate dehydrogenase (DHOD) inhibititon assays are utilized in a method for identifying new fungicides; DHOD inhibitors are useful in fungicidal methods and compositions. Resistance genes that are mutants of the wild-type Aspergillus nidulans dihydroorotate dehydrogenase gene have been isolated and found to impart resistance to certain DHOD inhibitors. The resistance genes are useful as selectable markers in fungi. The wild-type gene is also provided.

Method of identifying potential fungicides using dihydroorotate

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Indianapolis, IN, United States of America

Matthew J Henry