Bristol-myers Squibb Compnay

Mary Jo Donovan

Ramesh N Patel

Steven L Goldberg

Laszlo J Szarka

Ronald L Hanson

John J Venit

Paul Alan Jass

Keith Ramig

Wen-sen Li

Robert M Johnston

Venkata B Nanduri

Animesh Goswami

Linda Chu

K David Mirfakhrae

The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.

Stereoselective reduction of substituted acetophenone

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Stereoselective reductive amination of ketones

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North Brunswick, NJ, United States of America

Mary Jo Donovan