Sanofi

Marta Amaral

Gerhard Hessler

Ercole Rao

Christian Lange

Christian Beil

Ingo Focken

Wulf-Dirk Leuschner

Sandra Weil

Soraya Hoelper

Garima Tiwari

Jennifer Jung

Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Multispecific binding proteins with mutant fab domains

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Frankfurt-am-Main, Germany

Marta Amaral