Itm Isotopen Technologien Munchen Ag

Itm Isotope Technologies Munich Se

Actinium Pharmaceuticals, Limited

Oncobeta International Gmbh

Isotopen Technologien Munchen Ag

Mark Harfensteller

Tuomo Nikula

Konstantin Zhernosekov

Michael Schilp

Oliver Buck

Jussi Jernström

Jussi Jernstrom

Josue Manuel Moreno Bermudez

Richard Henkelmann

Maria Desantis

Cesidio Cipriani

Ernst Huenges

Marian Meckel

Jacek Koziorowski

Nikula Tuomo

Karl-Heinz Schneider

Lisa Maria Ehrenfried

Andreas Eursch

Julian Bernd Sonnenhol

Siegfried Förg

Max Bichlmaier

Sebastian Marx

Yury Totskiy

Nevzat Kelmendi

Andreas Tuerler

Ernst Hueenges

Mauritius W Geerlings

Siegfried Foerg

A method and an apparatus for producing radionuclide-containing products having substantially the identical desired activity of radioactivity at different times of application, with respect to a given calibration time. The method according to the invention allows to ensure a consistent composition of the desired radionuclide-labeled pharmaceutical at all times of application within the shelf life through a single manufacturing process. With the present invention it is possible, for example, to provide [n.c.a. Lu-177]Lu-DOTATOC on each working day of the week with constant activity at the respective time of application in a single manufacturing step.

Radiopharmaceuticals at different activity reference times

A method for the manufacture of highly purifiedGe material for radiopharmaceutical purposes. The invention particularly concerns the production ofGe-API (API=Active Pharmaceutical Ingredient) solution complying with the Guidelines for good manufacturing practices (GMP). Starting material for the method of the present invention can be aGe stock solution of commercial or other origin as raw material. SuchGe containing raw solutions are purified from potential metal and organic impurities originating from production processes. The radiochemical method disclosed is based on a twofold separation ofGe from organic and metallic impurities with two different adsorbent materials. During the first separation phaseGe is purified from both organic and metallic impurities by adsorption in germanium tetrachloride form, after which hydrolyzedGe is purified from remaining metallic impurities by cation exchange. The finalGe-API-product e.g. fulfills the regulatory requirements for specifications of the GMP production ofGe/Ga generators.

Method for the manufacture of highly purified 68Ge material for radiopharmaceutical purposes

AGe/Ga generator for a continuous production of aGa daughter nuclide, wherein theGe parent nuclide thereof is specifically adsorbed to an inorganic support material and wherein saidGe parent nuclide continuously decays toGa by electron capture at a half-life of 270.82 d, wherein the inorganic support material is at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum. The use of at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum as an inorganic support material for the manufacture of aGe/Ga generator for pharmaceutical purposes. With the inorganic support material of the present invention, it is possible to loadGe/Ga generators with up to 8000 MBq ofGe (corresponding to 80 &#x3bc;g Germanium).

68Ge/68Ga generator

The present invention relates to a column chromatographic method of manufacturing non-carrier-added high-purityLu compounds for medicinal purposes. In the method in accordance with the invention a cation exchanger and a suitable chelating agent are used. With the method in accordance with the invention it is possible for the first time to provide non-carrier-added high-purityLu compounds in milligram amounts for pharmaceutical-medicinal purposes fromYb compounds irradiated with thermal neutrons, the radionuclidesLu andYb being present in an approximate mass ratio of 1:10to 1:10for purification.

[object Object]

An applicator for applying a radioactive substance to a biological tissue, the applicator comprising a container for receiving the radioactive substance; an application device connectable to the container, by which the substance compound can be applied to the tissue; and at least a part of a conveying device by which the radioactive substance can be supplied from the container into the application device when the application device has been connected to the container.

Applicator for applying a radioactive substance to a biological tissue

The present invention refers to a method for producing a radium target for the production of radionuclides by means of accelerated protons, whereby at least one radium containing material out of an aqueous-organic solution or suspension of such a material is applied by means of a dispersing device on a surface in such a way that the dispersing device and the surface are moving relatively towards each other and that the solvent is removed substantially spontaneously. Further, the invention refers to a radium target that is created in such a way that it may exhibit an activity of up to 1.5 curie. The radium targets according to the present invention serve for the production of the radionuclideAc, which may be used in nuclear medicine in the treatment of cancer, particularly in form of its daughter nuclideBi.

Radium target and method for producing it

The invention relates to an apparatus for preparing a small amount of a radioactive substance combination, including a one-part body, a mixing device integrated in the body and adapted to receive a small amount of chemical substances, and at least one receptacle integrated in the body and connected to the mixing device and adapted to hold a small amount of a chemical substance.

Apparatus for and method of preparing a small amount of a radioactive substance combination

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Unterschleissheim, Germany

Mark Harfensteller