Indiana University

Xylogenics, Inc.

The United States Government As Represented by the Department of Veterans Affairs

Cocklin, Ross

Goebl, Mark

Woods, Cary

Heyen, Josh

Mark Gerard Goebl

Josh Heyen

Ross Cocklin

Cary Woods

Matthew S Kelker

Nadaraj Palaniappan

Kathryn A Houin

Joshua W Heyen

Ruben Sandoval

Bruce Molitoris

Mark C Wagner

Disclosed herein is a yeast strain capable of fermenting high maltose syrups into ethanol in the presence of glucose. In commercially important fuel ethanol yeast strains, the presence of glucose prevents robust maltose fermentation. This invention causes enhanced co-fermentation of maltose and glucose in strains otherwise identical to commercial fuel ethanol yeast strains.

Materials and methods for creating strains ofthat exhibit an increased ability to ferment oligosaccharides into ethanol

Disclosed herein are materials and methods for the production of high concentrations of ethanol from plant starch material broken down into disaccharide and trisaccharide sugars such as maltose, isomaltose, and maltotriose from uncooked starch. Herein is also described use of a yeast strain capable of fermenting high maltose syrups into ethanol without the need to convert disaccharides or trisaccharides into glucose using exogenous glucoamylases.

Methods of fermenting mixtures that include di- and tri-saccharides formed at low temperature using a maltophilic yeast

Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants ofthat can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.

Materials and methods for identifying and using yeast strains that metabolize pentose sugars in the presence of D-glucose

Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.

Materials and methods for treating bacterial infections using C-1 gentamicin

Growing community of inventors

Indianapolis, IN, United States of America

Mark Gerard Goebl