Catalent U.k. Swindon Zydis Limited

Mymetics Corporation

Pevion Biotech Ag

Pevion Biotech Ltd.

Biolife Science Qld Limited

Mario Amacker

Rinaldo Zurbriggen

Sylvain Fleury

Yik Teng Wong

Andreas Kammer

Charli Smardon

Khojasteh Shirkhani

Antonius Johannes Hendrikus Stegmann

Silvia Rasi

Christian Moser

Nicole Westerfeld

The present disclosure is directed to oral vaccine dosage forms and processes for producing the oral vaccine dosage forms. The dosage forms include lipid-based vesicles (e.g., virosomes, liposomes) harboring an immunogenic amount of at least one vaccinal target molecule, with or without adjuvant. Specifically, Applicants discovered a combination of the composition of the liquid virosome concentrates, the composition of the base matrix for the solid dosage form formulation (excluding the virosome concentrate), and the manufacturing conditions for the dosage forms that can produce a freeze dried sublingual dosage form having physical robustness, particle and antigen integrity and stability.

Oral dispersible vaccine comprising virosomes

The present invention includes fusion peptides comprising fragments of the cancer-related protein Her2/neu, methods of preparing such fusion peptides, virosomes comprising such fusion peptides, and uses of such fusion peptides or virosomes for the prevention, treatment or amelioration of a cancer characterized by expression or over-expression of the Her2/neu protein.

Multiepitope vaccine for Her2/neu-associated cancers

The present invention relates to virosomes comprising hemagglutinin (HA) with improved fusion activity. Preferably, the HA comprised in said virosomes was derived from influenza virus produced in a cell line. The present invention also relates to compositions and a kit comprising the virosomes according to the invention. Further, the present invention relates to uses and methods involving said virosomes, as well as to a method for preparing same.

Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof

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Schmitten, Switzerland

Mario Amacker