Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Centre Hospitalier Universitaire De Toulouse

Institut Claudius Regaud

Universite Paul Sabatier Toulouse

Université Paul Sabatier (toulouse Iii)

Centre National De La Recherche Scientifique-cnrs

Marie Tosolini

Jean-Jacques Fournie

Mary Poupot

Philippe Rochaix

Loïc Ysebaert

Pierre Brousset

The present invention relates to antibodies targeting Tumor Associated Macrophages (TAMs) and uses thereof. The inventors investigated specific marker exposed on the surface of the macrophages associated to tumor in order to detect and target TAMs. They showed that sideroflexin 3, which is absent in normal macrophage, is expressed by tumor associated macrophages. The inventors further demonstrated that using antibody directed to sideroflexin 3, they depleted TAMs in PBMC sample obtained from LCC patient, and strongly reduced leukemic B cells number.

Antibodies targeting tumor associated macrophages and uses thereof

Growing community of inventors

Toulouse, France

Marie Tosolini